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LOXL4

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LOXL4
Identifiers
AliasesLOXL4, LOXC, lysyl oxidase like 4
External IDsOMIM: 607318; MGI: 1914823; HomoloGene: 12977; GeneCards: LOXL4; OMA:LOXL4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032211

NM_001164311
NM_053083

RefSeq (protein)

NP_115587

NP_001157783
NP_444313

Location (UCSC)Chr 10: 98.25 – 98.27 MbChr 19: 42.58 – 42.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene.[5][6]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138131Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025185Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T (Jun 2001). "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage". J Biol Chem. 276 (26): 24023–9. doi:10.1074/jbc.M100861200. PMID 11292829.
  6. ^ a b "Entrez Gene: LOXL4 lysyl oxidase-like 4".

Further reading

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